Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10735346 | 0.93 | KMT2A (0.48) | KMT2ACAPN1TACR1ACEMEN1 | |
| SCHEMBL14182572 | 0.83 | KMT2A (0.48) | KMT2ATACR1MEN1CTSKSLC6A2 | |
| SCHEMBL9864576 | 0.83 | POLB (0.48) | KMT2ACTSKSLC6A2SLC6A3TDP1 | |
| SCHEMBL28547510 | 0.82 | KMT2A (0.53) | KMT2ATACR1ACEMEN1SLC6A2 | |
| SCHEMBL7097431 | 0.82 | KMT2A (0.53) | KMT2ATACR1ACEMEN1SLC6A2 | |
| SCHEMBL8622468 | 0.82 | KMT2A (0.53) | KMT2ATACR1ACEMEN1SLC6A2 | |
| SCHEMBL8678564 | 0.80 | SLC15A1 (0.51) | CAPN1TACR1CTSKALDH1A1 | |
| SCHEMBL3370862 | 0.80 | KMT2A (0.60) | KMT2AACEMEN1POLBNPSR1 | |
| SCHEMBL3370856 | 0.80 | KMT2A (0.60) | KMT2AACEMEN1POLBNPSR1 | |
| SCHEMBL6025269 | 0.80 | KMT2A (0.60) | KMT2AACEMEN1POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5061722-A | Hypotensive agents; e.g. ramipril | HOECHST AG (DE) | 1991-10-29 | — | — | US | disclosed |
| US-5053519-A | Hypotensive agents; diuretics; vasodilation | HOECHST AG (DE) | 1991-10-01 | — | — | US | disclosed |
| US-4879403-A | AMINATION, CRYSTALLIZATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-07 | — | — | US | disclosed |
| US-4727160-A | HYPOTENSIVE INTERMEDIATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-02-23 | — | — | US | disclosed |
| US-4714708-A | Derivatives of cis, endo-2-azabicyclo[5.3.0]decane-3-carboxylic acid, and their use for treating hypertension | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-12-22 | — | — | US | disclosed |