Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10735346 | 0.87 | KMT2A (0.48) | KMT2ATDP1MAPTSLC6A2SLC6A3 | |
| SCHEMBL7097431 | 0.86 | KMT2A (0.53) | POLBKMT2ATDP1NPSR1SLC6A2 | |
| SCHEMBL28547510 | 0.86 | KMT2A (0.53) | POLBKMT2ATDP1NPSR1SLC6A2 | |
| SCHEMBL8622468 | 0.86 | KMT2A (0.53) | POLBKMT2ATDP1NPSR1SLC6A2 | |
| SCHEMBL14182572 | 0.84 | KMT2A (0.48) | KMT2APPARGPPARATDP1MAPT | |
| Trifluoroacetic Acid SCHEMBL9864408 | 0.83 | KMT2A (0.42) | POLBKMT2ATDP1MAPTNPSR1 | |
| SCHEMBL7328548 | 0.81 | ITGA4 (0.53) | POLBTDP1MAPTNPSR1CTSK | |
| SCHEMBL10447913 | 0.81 | ITGA4 (0.53) | POLBTDP1MAPTNPSR1CTSK | |
| SCHEMBL7328544 | 0.81 | ITGA4 (0.53) | POLBTDP1MAPTNPSR1CTSK | |
| SCHEMBL2140333 | 0.77 | POLB (0.53) | POLBSYKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5061722-A | Hypotensive agents; e.g. ramipril | HOECHST AG (DE) | 1991-10-29 | — | — | US | disclosed |
| US-5053519-A | Hypotensive agents; diuretics; vasodilation | HOECHST AG (DE) | 1991-10-01 | — | — | US | disclosed |
| US-4879403-A | AMINATION, CRYSTALLIZATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-07 | — | — | US | disclosed |
| US-4727160-A | HYPOTENSIVE INTERMEDIATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-02-23 | — | — | US | disclosed |