Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1833906 | 0.85 | KDM4E (0.41) | LMNACYP3A4CYP2D6MAPK1THPO | |
| SCHEMBL13026989 | 0.83 | KDM4E (0.44) | LMNACYP3A4CYP2D6KDM4EALDH1A1 | |
| SCHEMBL7481019 | 0.76 | ALDH1A1 (0.39) | LMNACYP3A4CYP2D6MAPK1THPO | |
| SCHEMBL9865748 | 0.76 | KDM4E (0.46) | LMNACYP3A4CYP2D6MAPK1THPO | |
| SCHEMBL8808254 | 0.75 | MAPT (0.51) | LMNACYP3A4CYP2D6MAPK1THPO | |
| SCHEMBL5459757 | 0.72 | ALDH1A1 (0.42) | LMNACYP3A4CYP2D6MAPK1THPO | |
| SCHEMBL1839692 | 0.72 | KDM4E (0.37) | LMNACYP3A4CYP2D6KDM4EALDH1A1 | |
| SCHEMBL8868463 | 0.71 | LMNA (0.43) | LMNACYP2D6KDM4EALDH1A1MEN1 | |
| SCHEMBL4347564 | 0.71 | KDM4E (0.43) | LMNACYP3A4CYP2D6MAPK1THPO | |
| SCHEMBL8868764 | 0.71 | MAPT (0.42) | LMNACYP3A4CYP2D6MAPK1THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5003077-A | Having a cycloheptimidazole nucleus; photostability; methine bond having an auxochrome | FUJI PHOTO FILM CO., LTD. (JP) | 1991-03-26 | — | — | US | disclosed |
| US-4900648-A | RECORDING, ERASING USING LASER BEAM, METHINE DYE | FUJI PHOTO FILM CO., LTD. (JP) | 1990-02-13 | — | — | US | disclosed |
| US-4814265-A | CONTAINING METHANE DYE | FUJI PHOTO FILM CO., LTD. (JP) | 1989-03-21 | — | — | US | disclosed |
| US-4356247-A | LITHOGRAPHY; PRINTING PLATES; PHOTORESISTS; HIGH-SPEED SENSITIZERS; SOTRAGE STABILITY | FUJI PHOTO FILM CO., LTD. (JP) | 1982-10-26 | — | — | US | disclosed |