Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ASAH1 | Q13510 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1577945 | 0.78 | SMN1; SMN2 (0.75) | SMN1; SMN2HTTLMNAALDH1A1NPC1 | |
| SCHEMBL18626198 | 0.76 | SMN1; SMN2 (0.63) | SMN1; SMN2HTTLMNAASAH1ALDH1A1 | |
| SCHEMBL4769824 | 0.76 | SMN1; SMN2 (0.67) | SMN1; SMN2HTTLMNAASAH1ALDH1A1 | |
| SCHEMBL9303009 | 0.75 | ACHE (0.64) | SMN1; SMN2ACHE | |
| SCHEMBL9149301 | 0.75 | SMN1; SMN2 (0.55) | SMN1; SMN2HTTLMNAASAH1ALDH1A1 | |
| SCHEMBL6681460 | 0.74 | RAB9A (0.46) | SMN1; SMN2LMNAALDH1A1NPC1RAB9A | |
| SCHEMBL21548219 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2HTTLMNAASAH1ALDH1A1 | |
| SCHEMBL8604263 | 0.73 | SMN1; SMN2 (0.63) | SMN1; SMN2HTTLMNAASAH1ALDH1A1 | |
| SCHEMBL8914641 | 0.73 | SMN1; SMN2 (0.63) | SMN1; SMN2HTTLMNAASAH1ALDH1A1 | |
| SCHEMBL7332230 | 0.73 | SMN1; SMN2 (0.63) | SMN1; SMN2HTTLMNAASAH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |