Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866363 | 0.91 | SCN5A (0.39) | RAB9AALDH1A1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL10368107 | 0.91 | SCN5A (0.39) | RAB9AALDH1A1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL9866419 | 0.84 | RAB9A (0.42) | RAB9AALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9867261 | 0.83 | HRH2 (0.35) | ALDH1A1KMT2ASMN1; SMN2MEN1L3MBTL1 | |
| SCHEMBL9864992 | 0.82 | HRH2 (0.40) | RAB9AALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9867300 | 0.81 | POLB (0.38) | RAB9AKMT2ASMN1; SMN2MEN1L3MBTL1 | |
| SCHEMBL9867294 | 0.81 | POLB (0.38) | RAB9AKMT2ASMN1; SMN2MEN1L3MBTL1 | |
| SCHEMBL9866425 | 0.81 | RAB9A (0.42) | RAB9AALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9867255 | 0.75 | ALDH1A1 (0.37) | RAB9AALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL9865750 | 0.75 | RAB9A (0.43) | RAB9AALDH1A1KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |