Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867300 | 1.00 | POLB (0.38) | POLBTDP1SCN5ASCN2ASMN1; SMN2 | |
| SCHEMBL9865565 | 0.85 | ADRB1 (0.38) | POLBTDP1SCN5ASCN2ASMN1; SMN2 | |
| SCHEMBL9866363 | 0.83 | SCN5A (0.39) | POLBTDP1SCN5ASCN2ASMN1; SMN2 | |
| SCHEMBL10368107 | 0.83 | SCN5A (0.39) | POLBTDP1SCN5ASCN2ASMN1; SMN2 | |
| SCHEMBL9865114 | 0.82 | SCN5A (0.44) | POLBTDP1SCN5ASCN2ASMN1; SMN2 | |
| SCHEMBL9865122 | 0.82 | SCN5A (0.44) | POLBTDP1SCN5ASCN2ASMN1; SMN2 | |
| SCHEMBL9865887 | 0.82 | SCN5A (0.45) | POLBTDP1SCN5ASCN2ASMN1; SMN2 | |
| SCHEMBL9865894 | 0.82 | SCN5A (0.45) | POLBTDP1SCN5ASCN2ASMN1; SMN2 | |
| SCHEMBL9866877 | 0.82 | HRH3 (0.35) | HPGDMTNR1BL3MBTL1HRH3MTNR1A | |
| SCHEMBL9864984 | 0.81 | RAB9A (0.42) | POLBSCN5ASCN2ASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |