Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866370 | 0.91 | HPGD (0.38) | HRH2SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL9866425 | 0.84 | RAB9A (0.42) | HRH2ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9864984 | 0.82 | RAB9A (0.42) | HRH2ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9867306 | 0.81 | MTNR1A (0.42) | HRH2ALDH1A1 | |
| SCHEMBL9866419 | 0.81 | RAB9A (0.42) | HRH2ALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9867255 | 0.75 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2KMT2AMEN1RAB9A | |
| SCHEMBL9865765 | 0.75 | RAB9A (0.47) | HRH2ALDH1A1SMN1; SMN2KMT2ARAB9A | |
| SCHEMBL11080978 | 0.75 | HRH2 (0.47) | HRH2RAB9AHRH4NPC1 | |
| SCHEMBL9866479 | 0.75 | RAB9A (0.42) | HRH2ALDH1A1SMN1; SMN2KMT2ARAB9A | |
| SCHEMBL9867649 | 0.74 | LMNA (0.49) | HRH2ALDH1A1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |