Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 2/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865745 | 0.80 | SIGMAR1 (0.42) | MAPTSIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL49570 | 0.75 | SIGMAR1 (0.47) | MAPTSIGMAR1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8589377 | 0.74 | GABRA1 (0.40) | MAPTKMT2AMEN1SMN1; SMN2CRHBP | |
| SCHEMBL4083264 | 0.73 | NPC1 (0.48) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL6380460 | 0.69 | NPC1 (0.46) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL24815612 | 0.67 | ALDH1A1 (0.50) | MAPTKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL15261382 | 0.67 | ALDH1A1 (0.50) | MAPTKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL15274890 | 0.67 | SIGMAR1 (0.47) | MAPTKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL21102318 | 0.67 | SIGMAR1 (0.47) | MAPTKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL9288060 | 0.67 | ALOX5AP (0.46) | MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011938-A | Antimicrobials | ELI LILLY AND COMPANY (US) | 1991-04-30 | — | — | US | disclosed |
| US-4940718-A | BACTERICIDES | ELI LILLY AND COMPANY (US) | 1990-07-10 | — | — | US | disclosed |
| EP-0202046-A1 | 7-Substituted bicyclic pyrazolidinones | ELI LILLY AND COMPANY (US) | 1986-11-20 | — | — | EP | disclosed |