Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 5/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865576 | 1.00 | ADRB1 (0.40) | ADRB1ADRB3ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9865763 | 0.88 | ADRB1 (0.44) | ADRB1ADRB3ALDH1A1CYP1A2MEN1 | |
| SCHEMBL9866310 | 0.86 | ABCB1 (0.42) | ALDH1A1MEN1KMT2A | |
| SCHEMBL10371356 | 0.86 | ABCB1 (0.42) | ALDH1A1MEN1KMT2A | |
| SCHEMBL9865565 | 0.86 | ADRB1 (0.38) | ADRB1ADRB3CYP3A4MEN1KMT2A | |
| SCHEMBL9865129 | 0.85 | NPC1 (0.48) | MEN1KMT2ASCN5ASCN2APOLB | |
| SCHEMBL9865905 | 0.85 | NPC1 (0.46) | MEN1KMT2ASCN5ASCN2APOLB | |
| SCHEMBL9867306 | 0.85 | MTNR1A (0.42) | ALDH1A1SCN5ASCN2A | |
| SCHEMBL9865894 | 0.83 | SCN5A (0.45) | MEN1KMT2ASCN5ASCN2APOLB | |
| SCHEMBL9865887 | 0.83 | SCN5A (0.45) | MEN1KMT2ASCN5ASCN2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |