Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865552 | 0.85 | ADRB1 (0.40) | SCN5ASCN2AALDH1A1 | |
| SCHEMBL9865576 | 0.85 | ADRB1 (0.40) | SCN5ASCN2AALDH1A1 | |
| SCHEMBL9866370 | 0.83 | HPGD (0.38) | SCN5ASCN2AHRH2 | |
| SCHEMBL9865905 | 0.82 | NPC1 (0.46) | SCN5ASCN2AHRH2 | |
| SCHEMBL9865129 | 0.82 | NPC1 (0.48) | MTNR1AMTNR1BSCN5ASCN2AHRH2 | |
| SCHEMBL9864992 | 0.81 | HRH2 (0.40) | ALDH1A1HRH2 | |
| SCHEMBL9865894 | 0.80 | SCN5A (0.45) | SCN5ASCN2AHRH2 | |
| SCHEMBL9865887 | 0.80 | SCN5A (0.45) | SCN5ASCN2AHRH2 | |
| SCHEMBL9867294 | 0.80 | POLB (0.38) | MTNR1AMTNR1BSCN5ASCN2AKAT6A | |
| SCHEMBL9867300 | 0.80 | POLB (0.38) | MTNR1AMTNR1BSCN5ASCN2AKAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |