Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.59 |
| ▸ | HTR2A | P28223 | 3/20 | 0.59 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | HTR7 | P34969 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 3/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.56 |
| ▸ | HTR3A | P46098 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866367 | 0.82 | HRH3 (0.52) | HTR1AHTR2AHTR2CHTR7DRD3 | |
| SCHEMBL27236993 | 0.75 | DRD3 (1.00) | HTR1AHTR2AHTR2CHTR7DRD3 | |
| SCHEMBL14310794 | 0.74 | HRH3 (0.72) | HRH3HTR3A | |
| SCHEMBL9865351 | 0.74 | HTR1A (0.53) | HTR1AHTR2AHTR2CHTR7DRD3 | |
| Hydrochloric Acid SCHEMBL10445023 | 0.73 | HTR1A (0.51) | HTR1AHTR2AHTR2CHTR7DRD3 | |
| Hydrochloric Acid SCHEMBL10445024 | 0.73 | HTR1A (0.51) | HTR1AHTR2AHTR2CHTR7DRD3 | |
| SCHEMBL27583958 | 0.72 | HRH3 (0.57) | HTR2AHRH3 | |
| SCHEMBL1376529 | 0.72 | HRH3 (1.00) | HTR1AHTR2AHTR2CHTR7DRD3 | |
| SCHEMBL1375437 | 0.70 | HRH3 (0.73) | HRH3 | |
| SCHEMBL6104659 | 0.70 | HRH3 (0.57) | HTR2AHRH3MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |