Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865668 | 1.00 | TSHR (0.42) | TSHRRECQLHTTPOLBMAPT | |
| SCHEMBL9867649 | 0.86 | LMNA (0.49) | HTTMAPTLMNAALDH1A1KDM4E | |
| SCHEMBL9869252 | 0.86 | PSMB5 (0.48) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9866501 | 0.86 | PSMB5 (0.48) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9865681 | 0.85 | HTT (0.41) | TSHRRECQLHTTPOLBMAPT | |
| SCHEMBL9866425 | 0.84 | RAB9A (0.42) | POLBMAPTLMNAALDH1A1NPC1 | |
| SCHEMBL9866423 | 0.83 | HRH2 (0.41) | HTTMAPTL3MBTL1LMNATHRB | |
| SCHEMBL9867011 | 0.83 | LMNA (0.43) | HTTLMNAALDH1A1KDM4ENPC1 | |
| SCHEMBL9865848 | 0.83 | ALDH1A1 (0.39) | LMNAALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL9866151 | 0.83 | LMNA (0.39) | HTTMAPTLMNAALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |