Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 4/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866501 | 1.00 | PSMB5 (0.48) | PSMB5LMNASMN1; SMN2HRH2CYSLTR1 | |
| SCHEMBL9866505 | 0.94 | PSMB5 (0.44) | PSMB5LMNASMN1; SMN2HRH2CYSLTR1 | |
| SCHEMBL9867649 | 0.87 | LMNA (0.49) | LMNASMN1; SMN2HRH2HRH4ALDH1A1 | |
| SCHEMBL9866151 | 0.87 | LMNA (0.39) | PSMB5LMNASMN1; SMN2HRH2HRH4 | |
| SCHEMBL9866425 | 0.87 | RAB9A (0.42) | LMNASMN1; SMN2HRH2HRH4ALDH1A1 | |
| SCHEMBL9865668 | 0.86 | TSHR (0.42) | LMNASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL9865675 | 0.86 | TSHR (0.42) | LMNASMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL9865848 | 0.85 | ALDH1A1 (0.39) | PSMB5LMNASMN1; SMN2HRH2HRH4 | |
| SCHEMBL9867011 | 0.84 | LMNA (0.43) | LMNASMN1; SMN2HRH2HRH4ALDH1A1 | |
| SCHEMBL9866012 | 0.84 | LMNA (0.53) | LMNASMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |