Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | DPP4 | P27487 | 1/20 | 0.52 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HTR1F | P30939 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1838212 | 0.89 | MEN1 (0.61) | ALDH1A1DPP4DPP7MEN1KMT2A | |
| SCHEMBL10637954 | 0.87 | QDPR (0.49) | DPP4DPP7MEN1KMT2AHSD11B1 | |
| SCHEMBL10396188 | 0.85 | HTR1F (0.67) | ALDH1A1MEN1KMT2AHTR1FMAPT | |
| SCHEMBL10966560 | 0.84 | HSD11B1 (0.50) | DPP4DPP7MEN1KMT2AHSD11B1 | |
| SCHEMBL229876 | 0.83 | HSD11B1 (0.65) | ALDH1A1MEN1KMT2AHSD11B1 | |
| SCHEMBL11111271 | 0.82 | HSD11B1 (0.59) | MEN1KMT2AHSD11B1LMNA | |
| SCHEMBL10395236 | 0.81 | CPS1 (0.55) | ALDH1A1MEN1KMT2AHSD11B1 | |
| SCHEMBL6212608 | 0.79 | HSD11B1 (0.74) | ALDH1A1HSD11B1LMNAGAA | |
| SCHEMBL11619437 | 0.79 | CPS1 (0.56) | MEN1KMT2AHSD11B1 | |
| SCHEMBL7413579 | 0.78 | HSD11B1 (0.67) | ALDH1A1MEN1KMT2AHTR1FHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057611-A | Intermediates for analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4833244-A | Ethanobenzazepines | HOECHST-ROUSEEL PHARMACEUTICALS INC. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4723009-A | USING 1-OXA-6-AZA SPIRO(2,5)OCTANE COMPOUNDS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-02-02 | — | — | US | disclosed |
| US-4654336-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-03-31 | — | — | US | disclosed |
| EP-0200052-A2 | Ethanobenzazepines, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-11-05 | — | — | EP | disclosed |