Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866893 | 0.83 | MMP2 (0.56) | ALDH1A1KMT2ACHEK2MMP2MMP9 | |
| SCHEMBL10555120 | 0.81 | NPC1 (0.47) | NPBWR1NPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL13041693 | 0.81 | NPBWR1 (0.64) | NPBWR1NPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL10357617 | 0.80 | RHEB (0.65) | NPC1RAB9AALDH1A1MAPTNFKB1 | |
| SCHEMBL9378391 | 0.78 | PDE4A (0.53) | NPBWR1NPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL25722414 | 0.77 | HPSE (0.64) | NPBWR1NPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL34960 | 0.75 | NPC1 (0.60) | NPBWR1NPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL12304983 | 0.75 | NPBWR1 (0.69) | NPBWR1NPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL13183701 | 0.75 | NPC1 (0.78) | NPBWR1NPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL7574964 | 0.75 | NPC1 (0.58) | NPBWR1NPC1RAB9AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292348-B1 | POLYCYCLIC HETEROCYCLIC DERIVATIVES, PROCES FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINES | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA Groupement d'Intérêt Economique dit: (FR) | 1990-09-19 | — | — | EP | claimed |
| EP-0292348-A1 | Polycyclic heterocyclic derivatives, proces for their preparation and their use in human and veterinary medicines | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA Groupement d'Intérêt Economique dit: (FR) | 1988-11-23 | — | — | EP | claimed |
| US-RE33533-E | Skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1991-02-05 | — | — | US | disclosed |
| EP-0292348-B1 | POLYCYCLIC HETEROCYCLIC DERIVATIVES, PROCES FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINES | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA Groupement d'Intérêt Economique dit: (FR) | 1990-09-19 | — | — | EP | disclosed |
| US-4874747-A | DERMATOLOGY | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1989-10-17 | — | — | US | disclosed |
| EP-0292348-A1 | Polycyclic heterocyclic derivatives, proces for their preparation and their use in human and veterinary medicines | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA Groupement d'Intérêt Economique dit: (FR) | 1988-11-23 | — | — | EP | disclosed |