Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | MMP8 | P22894 | 1/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | RARB | P10826 | 8/20 | 0.55 |
| ▸ | RARG | P13631 | 8/20 | 0.55 |
| ▸ | RARA | P10276 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.53 |
| ▸ | RXRA | P19793 | 2/20 | 0.50 |
| ▸ | MPL | P40238 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | RXRG | P48443 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10357617 | 0.87 | RHEB (0.65) | MMP2MMP9MMP8MMP13KDM4E | |
| SCHEMBL9067619 | 0.84 | RARB (0.60) | RARBRARGRARAKDM4EALDH1A1 | |
| SCHEMBL8458879 | 0.84 | RARB (0.60) | MMP2MMP9MMP8MMP13RARB | |
| SCHEMBL9866153 | 0.83 | NPBWR1 (0.51) | MMP2MMP9MMP8MMP13ALDH1A1 | |
| SCHEMBL9379926 | 0.82 | RARB (0.52) | MMP2MMP9MMP8MMP13RARB | |
| SCHEMBL9067583 | 0.77 | RARB (0.64) | RARBRARGRARACHEK2RXRA | |
| SCHEMBL7602620 | 0.77 | KDM4E (0.70) | MMP2MMP9MMP8MMP13KDM4E | |
| SCHEMBL11599478 | 0.77 | KDM4E (0.70) | MMP2MMP9MMP8MMP13KDM4E | |
| SCHEMBL20982511 | 0.77 | MMP2 (0.78) | MMP2MMP9MMP8MMP13KDM4E | |
| SCHEMBL5219768 | 0.77 | NR4A2 (0.83) | MMP2MMP9MMP8MMP13KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292348-B1 | POLYCYCLIC HETEROCYCLIC DERIVATIVES, PROCES FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINES | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA Groupement d'Intérêt Economique dit: (FR) | 1990-09-19 | — | — | EP | claimed |
| US-RE33533-E | Skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1991-02-05 | — | — | US | disclosed |
| US-4874747-A | DERMATOLOGY | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1989-10-17 | — | — | US | disclosed |