Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867300 | 0.82 | POLB (0.38) | HRH3L3MBTL1MTNR1AMTNR1BADRB1 | |
| SCHEMBL9867294 | 0.82 | POLB (0.38) | HRH3L3MBTL1MTNR1AMTNR1BADRB1 | |
| SCHEMBL9866299 | 0.81 | HRH4 (0.37) | HRH3HRH4CYP2D6 | |
| SCHEMBL9867357 | 0.80 | SCN5A (0.43) | HRH3HRH4L3MBTL1 | |
| SCHEMBL9865960 | 0.80 | SCN5A (0.42) | HRH3HRH4L3MBTL1RECQL | |
| SCHEMBL9866870 | 0.79 | MTNR1A (0.44) | HRH3MAOAPTGS1LMNAL3MBTL1 | |
| SCHEMBL9867261 | 0.77 | HRH2 (0.35) | HRH4LMNAL3MBTL1CYP2D6 | |
| SCHEMBL9866068 | 0.74 | ADRB1 (0.39) | LMNAADRB2ADRB1CYP2D6ADRB3 | |
| SCHEMBL9866059 | 0.74 | ADRB1 (0.41) | LMNAADRB2ADRB1CYP2D6ADRB3 | |
| SCHEMBL9828417 | 0.73 | KDM1A (0.47) | MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |