Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 6/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867346 | 0.85 | HRH3 (0.45) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9866682 | 0.85 | ADRB2 (0.47) | ADRB1ADRB3CYP2D6ADRB2MEN1 | |
| SCHEMBL9865953 | 0.84 | HRH3 (0.44) | MEN1KMT2AMAPTSMN1; SMN2TSHR | |
| SCHEMBL9866870 | 0.84 | MTNR1A (0.44) | ADRB1ADRB3CYP2D6ADRB2MEN1 | |
| SCHEMBL9866679 | 0.81 | PRMT5 (0.45) | LMNA | |
| SCHEMBL9866068 | 0.79 | ADRB1 (0.39) | ADRB1ADRB3CYP2D6ADRB2MEN1 | |
| SCHEMBL9867117 | 0.79 | L3MBTL1 (0.43) | CYP2D6KMT2A | |
| SCHEMBL9709892 | 0.78 | KDM1A (0.40) | ALDH1A1LMNAMAPTSMN1; SMN2CASR | |
| SCHEMBL9828126 | 0.78 | EPHX2 (0.39) | — | |
| SCHEMBL9866251 | 0.77 | SIGMAR1 (0.42) | KMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021431-A | H-1 antagonist, h-2 agonist for treating hypertension, cardiac disease or arterial occlusion | HEUMANN PHARMA GMBH & CO. (DE) | 1991-06-04 | — | — | US | disclosed |
| EP-0199845-B1 | IMIDAZOLYLALKYLGUANIDIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1990-08-01 | — | — | EP | disclosed |
| EP-0199845-A1 | Imidazolylalkylguanidin derivatives, process for their preparation and pharmaceutical compositions containing them | HEUMANN PHARMA GMBH & CO (DE) | 1986-11-05 | — | — | EP | disclosed |