Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9335838 | 0.82 | HPSE (0.56) | HDAC1HDAC2HDAC3HPSEKMT2A | |
| SCHEMBL9865584 | 0.82 | NAMPT (0.60) | NAMPTHDAC1HDAC2HDAC3NR1H4 | |
| SCHEMBL9865137 | 0.81 | NAMPT (0.68) | NAMPTHDAC1HDAC2HDAC3KMT2A | |
| SCHEMBL9867345 | 0.75 | NAMPT (0.52) | NAMPTNR1H4HTT | |
| SCHEMBL27373249 | 0.75 | MGLL (0.60) | ENPP2HTT | |
| SCHEMBL996878 | 0.75 | NAMPT (0.78) | NAMPTHDAC1HDAC2HDAC3 | |
| SCHEMBL995725 | 0.74 | NAMPT (1.00) | NAMPTHDAC1HDAC2HDAC3 | |
| SCHEMBL7514786 | 0.72 | HTT (0.73) | HDAC1HDAC2HDAC3KMT2AHTT | |
| SCHEMBL13418126 | 0.72 | HTT (0.61) | HDAC2KMT2AHTT | |
| SCHEMBL127662 | 0.72 | HTT (0.82) | KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5039805-A | Novel benzoic and phenylacetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-08-13 | — | — | US | disclosed |
| EP-0372486-A2 | Benzoic-acid phenylacetic-acid derivatives, their preparation and their use as medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1990-06-13 | — | — | EP | disclosed |