Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.48 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867345 | 0.94 | NAMPT (0.52) | NAMPTPAX8NR1H4LMNAMAPK1 | |
| SCHEMBL9864590 | 0.87 | PAX8 (0.52) | NAMPTPAX8NR1H4LMNAKDM1A | |
| SCHEMBL9865137 | 0.87 | NAMPT (0.68) | NAMPTHDAC1HDAC2HDAC3NR1H4 | |
| SCHEMBL9866050 | 0.86 | GAA (0.54) | LMNAKDM1AMAOAKDM1BRCOR1 | |
| SCHEMBL9865717 | 0.83 | KDM1A (0.48) | PAX8NR1H4LMNAKDM1AMAOA | |
| SCHEMBL9865134 | 0.83 | HTT (0.53) | PAX8ALDH1A1HPGDHTT | |
| SCHEMBL9335791 | 0.82 | HTT (0.49) | HDAC1HDAC2HDAC3PAX8HTT | |
| SCHEMBL9335708 | 0.82 | NR1H4 (0.49) | PAX8NR1H4LMNAKDM1AMAOA | |
| SCHEMBL9867342 | 0.82 | NAMPT (0.59) | NAMPTHDAC1HDAC2HDAC3NR1H4 | |
| SCHEMBL9867129 | 0.82 | HDAC6 (0.49) | HDAC1HDAC2HDAC3PAX8HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5039805-A | Novel benzoic and phenylacetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1991-08-13 | — | — | US | disclosed |
| EP-0372486-A2 | Benzoic-acid phenylacetic-acid derivatives, their preparation and their use as medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1990-06-13 | — | — | EP | disclosed |