Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.38 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 6/20 | 0.39 |
| ▸ | ACHE | P22303 | 6/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9601971 | 0.93 | KCNH2 (0.39) | BCHEACHEKMT2AKCNH2MCHR1 | |
| Fumaric Acid SCHEMBL9602442 | 0.90 | KMT2A (0.42) | L3MBTL1POLBBCHEACHEMEN1 | |
| Fumaric Acid SCHEMBL9602434 | 0.90 | KMT2A (0.42) | L3MBTL1POLBBCHEACHEMEN1 | |
| Fumaric Acid SCHEMBL9603068 | 0.84 | ALDH1A1 (0.34) | L3MBTL1POLBMEN1KMT2ARAD52 | |
| SCHEMBL9601582 | 0.82 | MAPK14 (0.40) | MEN1KMT2AALDH1A1GAAMAPT | |
| SCHEMBL9603113 | 0.80 | MAPT (0.37) | MEN1KMT2AALDH1A1GAAMAPT | |
| Fumaric Acid SCHEMBL10445212 | 0.78 | KMT2A (0.40) | L3MBTL1POLBMEN1KMT2ARAD52 | |
| SCHEMBL10561829 | 0.77 | MAPT (0.42) | POLBACHEMEN1KMT2AALDH1A1 | |
| SCHEMBL10562323 | 0.76 | PDE4A (0.40) | L3MBTL1POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL9602381 | 0.75 | TDP1 (0.39) | MEN1KMT2AALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |