Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 5/20 | 0.37 |
| ▸ | CCND1 | P24385 | 5/20 | 0.37 |
| ▸ | CCND2 | P30279 | 5/20 | 0.37 |
| ▸ | CCND3 | P30281 | 5/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9867764 | 0.93 | L3MBTL1 (0.40) | KCNH2MCHR1BCHEMAOAACHE | |
| SCHEMBL9601582 | 0.88 | MAPK14 (0.40) | MAOBCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10561829 | 0.82 | MAPT (0.42) | ACHEMAPTKMT2A | |
| SCHEMBL9603113 | 0.82 | MAPT (0.37) | MAPTKMT2A | |
| Fumaric Acid SCHEMBL9602434 | 0.82 | KMT2A (0.42) | BCHEACHEMAOBCYP2C19MAPT | |
| Fumaric Acid SCHEMBL9602442 | 0.82 | KMT2A (0.42) | BCHEACHEMAOBCYP2C19MAPT | |
| SCHEMBL9602381 | 0.80 | TDP1 (0.39) | CYP1A2SRCMAPTKMT2A | |
| SCHEMBL9602794 | 0.80 | CHRM2 (0.32) | KCNH2CYP1A2CYP2D6MAPTKMT2A | |
| SCHEMBL10562323 | 0.79 | PDE4A (0.40) | CYP1A2MAPTKMT2A | |
| SCHEMBL10562924 | 0.78 | CES2 (0.36) | ACHEMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | claimed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | claimed |
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |