Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 known ✓ | O00255 | 4/20 | 0.42 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 4/20 | 0.38 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9602442 | 1.00 | KMT2A (0.42) | KMT2AL3MBTL1MEN1RAD52GAA | |
| SCHEMBL9601582 | 0.93 | MAPK14 (0.40) | KMT2AMEN1GAAMAPTKDM4E | |
| Fumaric Acid SCHEMBL9867764 | 0.90 | L3MBTL1 (0.40) | KMT2AL3MBTL1MEN1RAD52GAA | |
| Fumaric Acid SCHEMBL9865749 | 0.88 | KMT2A (0.40) | KMT2AL3MBTL1MEN1RAD52GAA | |
| Fumaric Acid SCHEMBL10445212 | 0.88 | KMT2A (0.40) | KMT2AL3MBTL1MEN1RAD52GAA | |
| Fumaric Acid SCHEMBL9603065 | 0.86 | ALDH1A1 (0.34) | KMT2AL3MBTL1MEN1RAD52GAA | |
| Fumaric Acid SCHEMBL9603068 | 0.86 | ALDH1A1 (0.34) | KMT2AL3MBTL1MEN1RAD52GAA | |
| Fumaric Acid SCHEMBL10445064 | 0.84 | MAOB (0.44) | L3MBTL1KDM4EPOLBBCHEACHE | |
| Fumaric Acid SCHEMBL9865075 | 0.84 | MAOB (0.44) | L3MBTL1KDM4EPOLBBCHEACHE | |
| SCHEMBL9603113 | 0.81 | MAPT (0.37) | KMT2AMEN1GAAMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |