Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20422789 | 0.80 | ADORA3 (0.51) | PSMB8CYP1A2CYP3A4CYP2C19HSD17B10 | |
| SCHEMBL9867471 | 0.80 | NPC1 (0.42) | ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8621948 | 0.76 | PSMB8 (0.49) | PSMB8CYP1A2CYP3A4CYP2C19HSD17B10 | |
| SCHEMBL9867363 | 0.76 | NPC1 (0.62) | CYP1A2CYP3A4CYP2C19HSD17B10ALDH1A1 | |
| SCHEMBL9868463 | 0.76 | HSD17B10 (0.44) | HSD17B10ALDH1A1TDP1MAPK1LMNA | |
| SCHEMBL9868332 | 0.76 | PSMB8 (0.45) | PSMB8CYP1A2CYP3A4CYP2C19HSD17B10 | |
| SCHEMBL9868234 | 0.76 | L3MBTL1 (0.52) | CYP1A2CYP3A4CYP2C19HSD17B10TSHR | |
| SCHEMBL9867842 | 0.74 | RAB9A (0.40) | TSHRALDH1A1MAPK1LMNANPC1 | |
| SCHEMBL9866017 | 0.74 | PSMB8 (0.43) | PSMB8CYP1A2CYP3A4CYP2C19HSD17B10 | |
| SCHEMBL9868513 | 0.73 | NPC1 (0.39) | ALDH1A1NPC1RAB9ASMN1; SMN2TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | claimed |
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | disclosed |
| US-4873239-A | GLAUCOMA TREATMENT | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0276822-A1 | Arylthiadiazolylsulfonamides and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4758578-A | Arylthiadiazolylsulfonamides, pharmaceutical compositions and use | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-07-19 | — | — | US | disclosed |