Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | USP1 | O94782 | 11/20 | 0.34 |
| ▸ | WDR48 | Q8TAF3 | 9/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.33 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.33 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867842 | 0.77 | RAB9A (0.40) | NPC1RAB9ASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL9868463 | 0.76 | HSD17B10 (0.44) | NPC1RAB9ASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL9867471 | 0.76 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL9868267 | 0.74 | CA12 (0.49) | NPC1RAB9ASMN1; SMN2L3MBTL1CA12 | |
| SCHEMBL9867795 | 0.73 | PSMB8 (0.42) | NPC1RAB9ASMN1; SMN2USP1WDR48 | |
| SCHEMBL9875069 | 0.72 | CYP19A1 (0.41) | NPC1RAB9ASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL9867210 | 0.72 | ADORA3 (0.58) | NPC1RAB9ASMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL12444953 | 0.65 | PIP4K2C (0.47) | CA12CA1CA2CA9USP1 | |
| SCHEMBL167078 | 0.65 | GABRA1 (0.55) | NPC1RAB9ASMN1; SMN2L3MBTL1CA12 | |
| SCHEMBL29414063 | 0.65 | GABRA1 (0.55) | NPC1RAB9ASMN1; SMN2L3MBTL1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | claimed |
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | disclosed |
| US-4873239-A | GLAUCOMA TREATMENT | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0276822-A1 | Arylthiadiazolylsulfonamides and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4758578-A | Arylthiadiazolylsulfonamides, pharmaceutical compositions and use | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-07-19 | — | — | US | disclosed |