Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.38 |
| ▸ | MLKL | Q8NB16 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23680086 | 0.81 | — | — | |
| SCHEMBL13373326 | 0.74 | SMN1; SMN2 (0.41) | PRMT5SMN1; SMN2CHEK2MLKLHPGD | |
| SCHEMBL242516 | 0.74 | EIF4A3 (0.39) | SMN1; SMN2MLKLHPGDKDM4E | |
| SCHEMBL30462995 | 0.74 | KIF11 (0.37) | — | |
| Phenyl Ethanol SCHEMBL8646918 | 0.72 | MLKL (0.38) | SMN1; SMN2EGFRPIK3CAMLKLKDM4E | |
| SCHEMBL19523306 | 0.71 | — | — | |
| SCHEMBL1363970 | 0.71 | DYRK3 (0.54) | HPGDKDM4E | |
| SCHEMBL3725844 | 0.71 | UGT2B7 (0.37) | CHEK2MLKLKDM4E | |
| Hydrochloric Acid SCHEMBL8635004 | 0.71 | MLKL (0.47) | PRMT5SMN1; SMN2EGFRPIK3CACHEK2 | |
| SCHEMBL24494646 | 0.71 | L3MBTL1 (0.31) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5039677-A | Estrogen inhibitor | JANSSEN PHARMACEUTICA N.V. (CA) | 1991-08-13 | — | — | US | disclosed |
| US-4943574-A | AROMATASE INHIBITORS, ESTROGEN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |