Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 10/20 | 0.44 |
| ▸ | RARB | P10826 | 7/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | RARG | P13631 | 7/20 | 0.37 |
| ▸ | RARA | P10276 | 5/20 | 0.37 |
| ▸ | RXRB | P28702 | 8/20 | 0.36 |
| ▸ | RXRG | P48443 | 7/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11583537 | 0.87 | ALDH1A1 (0.39) | RXRARARBALDH1A1KDM4EMEN1 | |
| SCHEMBL9867812 | 0.84 | PTK2 (0.44) | RXRARARBTP53ALOX15CYP3A4 | |
| SCHEMBL15347776 | 0.84 | RXRA (0.50) | RXRARARBTP53CYP1A2CYP3A4 | |
| SCHEMBL29850490 | 0.82 | ALDH1A1 (0.36) | RXRAALDH1A1KDM4EMEN1GAA | |
| SCHEMBL14945765 | 0.82 | ALDH1A1 (0.36) | RXRAALDH1A1KDM4EMEN1GAA | |
| SCHEMBL18088472 | 0.80 | ALDH1A1 (0.35) | RXRAALDH1A1KDM4EMEN1GAA | |
| SCHEMBL14182660 | 0.79 | ALOX15 (0.42) | ALDH1A1KDM4EMEN1GAAMAPT | |
| SCHEMBL14182648 | 0.79 | ALOX15 (0.42) | ALDH1A1KDM4EMEN1GAAMAPT | |
| SCHEMBL6224470 | 0.76 | RXRA (0.46) | RXRARARBTP53CYP1A2ALDH1A1 | |
| SCHEMBL21440625 | 0.76 | RXRA (0.38) | RXRARARBTP53ALOX15CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292348-B1 | POLYCYCLIC HETEROCYCLIC DERIVATIVES, PROCES FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINES | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA Groupement d'Intérêt Economique dit: (FR) | 1990-09-19 | — | — | EP | claimed |
| EP-0292348-A1 | Polycyclic heterocyclic derivatives, proces for their preparation and their use in human and veterinary medicines | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA Groupement d'Intérêt Economique dit: (FR) | 1988-11-23 | — | — | EP | claimed |
| US-RE33533-E | Skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1991-02-05 | — | — | US | disclosed |
| EP-0292348-B1 | POLYCYCLIC HETEROCYCLIC DERIVATIVES, PROCES FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND VETERINARY MEDICINES | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA Groupement d'Intérêt Economique dit: (FR) | 1990-09-19 | — | — | EP | disclosed |
| US-4874747-A | DERMATOLOGY | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1989-10-17 | — | — | US | disclosed |
| EP-0292348-A1 | Polycyclic heterocyclic derivatives, proces for their preparation and their use in human and veterinary medicines | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA Groupement d'Intérêt Economique dit: (FR) | 1988-11-23 | — | — | EP | disclosed |