Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9868197 | 0.77 | PSEN1 (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4819807 | 0.68 | PSEN1 (0.78) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9866909 | 0.68 | ALDH1A1 (0.44) | ALDH1A1CYP2D6DPP4DPP7CYP3A4 | |
| SCHEMBL9868636 | 0.67 | ALDH1A1 (0.43) | ALDH1A1CYP2D6DPP4DPP7CYP3A4 | |
| SCHEMBL14263409 | 0.65 | CES2 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8067224 | 0.64 | OPRM1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6952918 | 0.64 | NOTUM (0.59) | ALDH1A1DPP4DPP7RORC | |
| SCHEMBL7324875 | 0.64 | DPP4 (0.49) | ALDH1A1CYP2D6DPP4DPP7RORC | |
| SCHEMBL18711298 | 0.63 | RORC (0.44) | ALDH1A1CYP2D6RORCMAPK1CYP2C19 | |
| SCHEMBL7701344 | 0.62 | DPP4 (0.46) | ALDH1A1CYP2D6DPP4DPP7CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057611-A | Intermediates for analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-10-15 | — | — | US | disclosed |
| US-4833244-A | Ethanobenzazepines | HOECHST-ROUSEEL PHARMACEUTICALS INC. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4723009-A | USING 1-OXA-6-AZA SPIRO(2,5)OCTANE COMPOUNDS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-02-02 | — | — | US | disclosed |
| US-4654336-A | ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-03-31 | — | — | US | disclosed |
| EP-0200052-A2 | Ethanobenzazepines, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-11-05 | — | — | EP | disclosed |