Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 10/20 | 0.43 |
| ▸ | PDE2A | O00408 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9868548 | 0.80 | SMN1; SMN2 (0.43) | PTGS2PTGS1PDE2ASMN1; SMN2LMNA | |
| SCHEMBL7159367 | 0.77 | PTGS1 (0.46) | PTGS2PTGS1KDM4E | |
| SCHEMBL22519204 | 0.68 | F2 (0.47) | SMN1; SMN2LMNAKDM4E | |
| SCHEMBL10481567 | 0.63 | KDM4E (0.50) | PTGS2PTGS1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL31294846 | 0.63 | BRD4 (0.51) | PDE2ASMN1; SMN2KDM4E | |
| SCHEMBL7162608 | 0.62 | TP53 (0.48) | PTGS2PTGS1SMN1; SMN2LMNA | |
| SCHEMBL5108776 | 0.60 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL25513553 | 0.60 | KDM4E (0.44) | KDM4E | |
| SCHEMBL24616836 | 0.59 | F2 (0.47) | SMN1; SMN2LMNAKDM4E | |
| SCHEMBL29243233 | 0.59 | KCNK2 (0.44) | PDE2ALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991002724-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1991-03-07 | — | — | WO | disclosed |