Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 5/20 | 0.53 |
| ▸ | KDM6B | O15054 | 4/20 | 0.53 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.53 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.53 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.53 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.53 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.53 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL258224 | 0.83 | KDM6B (0.59) | FTOKDM6BALKBH2ALKBH3KDM5B | |
| SCHEMBL7020789 | 0.81 | TSHR (0.53) | TSHR | |
| SCHEMBL9870441 | 0.80 | FTO (0.56) | FTOKDM6BALKBH2ALKBH3KDM5B | |
| SCHEMBL6491004 | 0.79 | FTO (0.56) | FTOKDM6BALKBH2ALKBH3KDM5B | |
| SCHEMBL7109229 | 0.77 | FTO (0.51) | FTOKDM6BALKBH2ALKBH3KDM5B | |
| SCHEMBL9870443 | 0.76 | FTO (0.52) | FTOKDM6BALKBH2ALKBH3KDM5B | |
| SCHEMBL11628317 | 0.74 | NAPRT (0.53) | FTOKDM6BALKBH2ALKBH3KDM5B | |
| SCHEMBL9868876 | 0.73 | FTO (0.50) | FTOKDM6BALKBH2ALKBH3KDM5B | |
| SCHEMBL4951259 | 0.73 | KDM4C (0.56) | FTOKDM6BALKBH2ALKBH3KDM5B | |
| SCHEMBL15109804 | 0.72 | KDM4E (0.44) | KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006532-A | Enzyme inhibitor; antiinflammatory agents | MERCK & CO. INC., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4904672-A | Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4767766-A | Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1988-08-30 | — | — | US | disclosed |