Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 4/20 | 0.56 |
| ▸ | KDM6B | O15054 | 2/20 | 0.56 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.56 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.56 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.56 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.56 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL258224 | 0.83 | KDM6B (0.59) | FTOKDM6BALKBH2ALKBH3KDM5B | |
| SCHEMBL9868876 | 0.82 | FTO (0.50) | FTOKDM6BALKBH2ALKBH3KDM5B | |
| SCHEMBL7439635 | 0.81 | ALDH1A1 (0.58) | ALDH1A1TSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL30465486 | 0.81 | KDM4E (0.57) | KDM6BALDH1A1TSHRTDP1KDM4E | |
| SCHEMBL905244 | 0.81 | ALDH1A1 (0.63) | ALDH1A1TSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4074620 | 0.81 | KDM4E (0.57) | KDM6BALDH1A1TSHRTDP1KDM4E | |
| SCHEMBL9870441 | 0.80 | FTO (0.56) | FTOKDM6BALKBH2ALKBH3KDM5B | |
| Bicarbonate SCHEMBL27492793 | 0.80 | ALDH1A1 (0.62) | ALDH1A1TSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9868870 | 0.79 | FTO (0.53) | FTOKDM6BALKBH2ALKBH3KDM5B | |
| SCHEMBL17078728 | 0.78 | ALDH1A1 (0.54) | ALDH1A1TSHRTDP1KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050010048-A1 | Aza-and polyaza-naphthalenly ketones useful as hiv integrase inhibitors | ZHUANG LINGHANG (US) | 2005-01-13 | — | — | US | disclosed |
| EP-1333831-A2 | AZA-AND POLYAZA-NAPHTHALENYL KETONES USEFUL AS HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002036734-A2 | AZA-AND POLYAZA-NAPHTHALENYL KETONES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050010048-A1 | Aza-and polyaza-naphthalenly ketones useful as hiv integrase inhibitors | POLI, CYP51A1, DUT | FTO 1240/4885KDM6B 926/4885ALKBH2 639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.