Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16394557 | 0.79 | SYK (0.42) | ALDH1A1SMN1; SMN2SYKKDM4EAURKB | |
| SCHEMBL493397 | 0.78 | HRH1 (0.52) | TDP1ALDH1A1SMN1; SMN2SYKKDM4E | |
| SCHEMBL465245 | 0.77 | HRH1 (0.44) | TDP1ALDH1A1SMN1; SMN2HRH1LMNA | |
| Hydrochloric Acid SCHEMBL27710379 | 0.76 | SMN1; SMN2 (0.50) | TDP1ALDH1A1SMN1; SMN2SYKKDM4E | |
| Hydrochloric Acid SCHEMBL28440523 | 0.75 | HRH1 (0.42) | TDP1ALDH1A1SMN1; SMN2HRH1LMNA | |
| SCHEMBL732958 | 0.74 | TDP1 (0.52) | TDP1ALDH1A1GLASMN1; SMN2TP53 | |
| SCHEMBL31677377 | 0.74 | TDP1 (0.56) | TDP1ALDH1A1GLASMN1; SMN2TP53 | |
| SCHEMBL6988371 | 0.74 | TDP1 (0.56) | TDP1ALDH1A1GLASMN1; SMN2TP53 | |
| SCHEMBL6988370 | 0.74 | TDP1 (0.56) | TDP1ALDH1A1GLASMN1; SMN2TP53 | |
| SCHEMBL306297 | 0.73 | LMNA (0.57) | TDP1ALDH1A1GLATSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4999361-A | Cardiovascular disorders, blood vessel relaxants | BOEHRINGER MANNHEIM GMBH (DE) | 1991-03-12 | — | — | US | disclosed |