Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870207 | 0.82 | KDM4E (0.49) | KDM4EALDH1A1GAAMAPTKMO | |
| SCHEMBL9870091 | 0.81 | KDM4E (0.55) | KDM4EALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL11009952 | 0.77 | CYP2A6 (0.46) | KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL11009148 | 0.75 | BACE1 (0.49) | KDM4EALDH1A1MAPTHSD17B10DYRK1A | |
| SCHEMBL5259449 | 0.75 | BACE1 (0.64) | KDM4EALDH1A1GAAMAPTCYP17A1 | |
| SCHEMBL9534839 | 0.74 | HSD17B10 (0.49) | KDM4EALDH1A1HSD17B10KMT2ADYRK1A | |
| SCHEMBL9869878 | 0.73 | KDM4E (0.44) | KDM4EALDH1A1GAAMAPTKMO | |
| SCHEMBL11467433 | 0.73 | KDM4E (0.54) | KDM4EALDH1A1GAAMAPTKMO | |
| SCHEMBL5262408 | 0.73 | GABRA1 (0.64) | — | |
| SCHEMBL11463603 | 0.72 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10CYP17A1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037980-A | Anxiolytic agents, hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1991-08-06 | — | — | US | claimed |
| US-5037980-A | Anxiolytic agents, hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1991-08-06 | — | — | US | disclosed |