Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11009148 | 0.87 | BACE1 (0.49) | KDM4EMAPTMAPK1ALDH1A1HPGD | |
| SCHEMBL11009952 | 0.86 | CYP2A6 (0.46) | KDM4EMAPTMAPK1ALDH1A1KDR | |
| SCHEMBL9870239 | 0.81 | KDM4E (0.43) | KDM4EMAPTALDH1A1HSD17B10DYRK1A | |
| SCHEMBL9869878 | 0.79 | KDM4E (0.44) | KDM4EMAPTMAPK1ALDH1A1HPGD | |
| SCHEMBL9870867 | 0.79 | GABRA1 (0.42) | KDM4EMAPTMAPK1CDK8MAP2K1 | |
| SCHEMBL9869785 | 0.75 | TUBB4A (0.45) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL259043 | 0.73 | KDM4E (0.50) | KDM4EMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL12395111 | 0.71 | PDE2A (0.38) | KDM4EMAPK1ALDH1A1HPGDADORA2A | |
| SCHEMBL1681613 | 0.70 | PDE2A (0.40) | KDM4EALDH1A1HPGDHSD17B10MAP2K1 | |
| SCHEMBL1681759 | 0.70 | DPP4 (0.39) | KDM4EALDH1A1HPGDMAP2K1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037980-A | Anxiolytic agents, hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1991-08-06 | — | — | US | disclosed |