Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9870091 | 0.79 | KDM4E (0.55) | KDM4EALDH1A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL11009148 | 0.79 | BACE1 (0.49) | KDM4EALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL11009952 | 0.75 | CYP2A6 (0.46) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL9870239 | 0.73 | KDM4E (0.43) | KDM4EALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL1681759 | 0.73 | DPP4 (0.39) | KDM4EALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL9869785 | 0.70 | TUBB4A (0.45) | KDM4EALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL9329531 | 0.70 | PDE2A (0.37) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL259043 | 0.69 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL9870867 | 0.69 | GABRA1 (0.42) | KDM4EMAPTMAPK1PDE2A | |
| SCHEMBL10562568 | 0.67 | HSD11B1 (0.46) | KDM4EALDH1A1SMN1; SMN2HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037980-A | Anxiolytic agents, hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1991-08-06 | — | — | US | claimed |
| US-5037980-A | Anxiolytic agents, hypotensive agents | AMERICAN CYANAMID COMPANY (US) | 1991-08-06 | — | — | US | disclosed |