SCHEMBL98704

SCHEMBL98704

O=C(O)Nc1cc(CCC(=O)Nc2ccc(CO)cc2)ccc1-c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 2/20 0.51
AKR1C2 P52895 2/20 0.51
MAPT P10636 3/20 0.50
HTT P42858 1/20 0.50
HCAR2 Q8TDS4 2/20 0.48
HDAC3 O15379 2/20 0.47
HDAC4 P56524 2/20 0.47
HDAC1 Q13547 2/20 0.47
HDAC7 Q8WUI4 2/20 0.47
HDAC2 Q92769 2/20 0.47
HDAC10 Q969S8 2/20 0.47
HDAC11 Q96DB2 2/20 0.47
HDAC8 Q9BY41 2/20 0.47
HDAC6 Q9UBN7 2/20 0.47
HDAC9 Q9UKV0 2/20 0.47
HDAC5 Q9UQL6 2/20 0.47
GAA P10253 2/20 0.47
RORC P51449 1/20 0.47
TOP2A P11388 1/20 0.46
TOP2B Q02880 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL101223 0.93 HDAC1 (0.51) AKR1C3AKR1C2MAPTHDAC3HDAC4
SCHEMBL101623 0.92 HDAC2 (0.48) MAPTHCAR2HDAC3HDAC4HDAC1
SCHEMBL99629 0.90 MAPT (0.50) AKR1C3AKR1C2MAPTHTTHCAR2
SCHEMBL99215 0.90 AKR1C3 (0.49) AKR1C3AKR1C2MAPTHTTHCAR2
SCHEMBL15821963 0.89 AKR1C3 (0.50) AKR1C3AKR1C2MAPTHTTHCAR2
SCHEMBL100326 0.87 HCAR2 (0.46) AKR1C3AKR1C2MAPTHTTHCAR2
SCHEMBL100288 0.86 PTGDR2 (0.46) AKR1C3AKR1C2MAPTHTTHCAR2
SCHEMBL100587 0.86 RORC (0.46) AKR1C3AKR1C2MAPTHCAR2HDAC3
SCHEMBL101142 0.85 AKR1C3 (0.53) AKR1C3AKR1C2MAPTHTTHCAR2
SCHEMBL99615 0.84 RAB9A (0.55) AKR1C3AKR1C2HCAR2GAARORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2426121-A1 QUATERNARY AMMONIUM SALT COMPOUND Teijin Pharma Limited (JP) 2012-03-07 EP claimed