Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9871413 | 0.85 | BRD4 (0.40) | ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL10759407 | 0.79 | RAB9A (0.35) | TDP1ATMALDH1A1RAB9APOLB | |
| SCHEMBL2944429 | 0.79 | RAB9A (0.35) | TDP1ATMRAB9APOLBSMN1; SMN2 | |
| SCHEMBL9168542 | 0.79 | RAB9A (0.35) | TDP1ATMRAB9APOLBSMN1; SMN2 | |
| SCHEMBL10790770 | 0.79 | RAB9A (0.35) | TDP1ATMRAB9APOLBSMN1; SMN2 | |
| SCHEMBL10493918 | 0.79 | ALDH1A1 (0.37) | ALDH1A1MAPTHPGDRAB9APOLB | |
| SCHEMBL9670137 | 0.79 | ALDH1A1 (0.39) | TDP1ALDH1A1MAPTHPGDRAB9A | |
| SCHEMBL9705614 | 0.79 | TDP1 (0.39) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL7186704 | 0.79 | TDP1 (0.39) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL10346269 | 0.78 | HTR2A (0.39) | ALDH1A1MAPTHPGDRAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021566-A | Carbapenicillins; preservatives; antiseptics; grampositive and gram negative bacteria | MERCK & CO. INC. (US) | 1991-06-04 | — | — | US | disclosed |
| US-4841042-A | Process for the preparation of carbapenem intermediates | BAYER AKTIENGESELLSCHAFT (DE) | 1989-06-20 | — | — | US | disclosed |
| US-4820817-A | Process for preparing 3-substituted-6-substituted-7-oxo-1-azabicycl(3.2.0)-hept-2-ene-2-carboxylic acid | MERCK & CO., INC. (US) | 1989-04-11 | — | — | US | disclosed |
| US-4745188-A | ANTIBIOTICS, SULFIDING | MERCK & CO., INC. (US) | 1988-05-17 | — | — | US | disclosed |
| US-4707547-A | AMINATION TO FORM ANTIBIOTIC | MERCK & CO., INC. (US) | 1987-11-17 | — | — | US | disclosed |
| EP-0195963-A1 | Process for the preparation of carbapenem intermediates | BAYER AG (DE) | 1986-10-01 | — | — | EP | disclosed |
| US-4530841-A | Antibiotic containing hetero ring | MERCK & CO., INC. (US) | 1985-07-23 | — | — | US | disclosed |
| EP-0134301-A1 | 6-(1'-Hydroxyethyl)-3-substituted amino-1-azabicyclo(3.2.0)-hept-2-en-7-one-2-carboxylic acid | MERCK & CO. INC. (US) | 1985-03-20 | — | — | EP | disclosed |
| US-4369187-A | AMINO ACID DERIVATIVE ANTIBIOTICS | MERCK & CO., INC. (US) | 1983-01-18 | — | — | US | disclosed |
| US-4357342-A | 1-Azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylic acid | MERCK & CO., INC. (US) | 1982-11-02 | — | — | US | disclosed |
| US-4318912-A | 6-(1-Hydroxyethyl)-3-substituted-1-azabicyclo(3.2.0)-hept-2-en-7-one-2-carboxylic acid | MERCK & CO., INC. (US) | 1982-03-09 | — | — | US | disclosed |
| US-4310538-A | BACTERICIDES | MERCK & CO., INC. (US) | 1982-01-12 | — | — | US | disclosed |