Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA1 | P15085 | 6/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1833635 | 0.84 | TRPA1 (0.55) | TRPA1ALPLPOLBALPGCYP1A2 | |
| SCHEMBL7804534 | 0.84 | CPA1 (0.64) | CPA1TRPA1ALPLPOLBALPG | |
| Ammonia Solution, Strong SCHEMBL29021310 | 0.82 | TRPA1 (0.53) | TRPA1ALPLPOLBALPGCYP1A2 | |
| Nitric Acid SCHEMBL11150616 | 0.82 | EPHX1 (0.68) | CPA1ALPIPKMPTGS1XIAP | |
| Benzyl Alcohol SCHEMBL2963501 | 0.80 | TSHR (0.67) | CPA1CYP1A2 | |
| SCHEMBL714764 | 0.79 | CPA1 (0.53) | CPA1ALPLPOLBALPGCYP1A2 | |
| Amphetamine SCHEMBL21464387 | 0.79 | TAAR1 (0.70) | CPA1ALPIPKMPTGS1XIAP | |
| Hypophosphorous Acid SCHEMBL3367718 | 0.78 | TRPA1 (0.52) | CPA1TRPA1ALPLPOLBALPG | |
| Dl-Phenylalanine SCHEMBL22440727 | 0.77 | SLC7A5 (0.79) | CPA1CYP1A2ALPIPKMPTGS1 | |
| Phenylalanine SCHEMBL4958693 | 0.77 | SLC7A5 (0.79) | CPA1CYP1A2ALPIPKMPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | disclosed |
| EP-0359335-A2 | Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance | CEDONA PHARMACEUTICALS B.V. (NL) | 1990-03-21 | — | — | EP | disclosed |