Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.79 |
| ▸ | ALPI | P09923 | 1/20 | 0.79 |
| ▸ | PKM | P14618 | 1/20 | 0.79 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.79 |
| ▸ | XIAP | P98170 | 1/20 | 0.79 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.57 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.57 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.57 |
| ▸ | CPA1 | P15085 | 6/20 | 0.56 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Phenylalanine SCHEMBL22440727 | 1.00 | SLC7A5 (0.79) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL8118 | 0.89 | SLC7A5 (1.00) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL16398197 | 0.89 | SLC7A5 (1.00) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL15671104 | 0.89 | SLC7A5 (1.00) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL8119 | 0.89 | SLC7A5 (1.00) | SLC7A5ALPIPKMPTGS1XIAP | |
| SCHEMBL23159186 | 0.89 | SLC7A5 (1.00) | SLC7A5ALPIPKMPTGS1XIAP | |
| D-Phenylalanine SCHEMBL837632 | 0.89 | SLC7A5 (1.00) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL385804 | 0.89 | SLC7A5 (1.00) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL16398196 | 0.89 | SLC7A5 (1.00) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL43671 | 0.89 | SLC7A5 (1.00) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12240819-B1 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2025-03-04 | — | — | US | claimed |
| US-12612370-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-04-28 | — | — | US | disclosed |
| US-12577210-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-03-17 | — | — | US | disclosed |
| US-12577209-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-03-17 | — | — | US | disclosed |
| US-12540119-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-02-03 | — | — | US | disclosed |
| US-12522568-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-01-13 | — | — | US | disclosed |
| US-12473261-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2025-11-18 | — | — | US | disclosed |
| US-12448357-B1 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2025-10-21 | — | — | US | disclosed |
| US-20250171406-A1 | AMINO ACID COMPOSITIONS | THERMOLIFE INTERNATIONAL, LLC | 2025-05-29 | — | — | US | disclosed |
| US-20250163001-A1 | AMINO ACID COMPOSITIONS | THERMOLIFE INTERNATIONAL, LLC | 2025-05-22 | — | — | US | disclosed |
| US-8546526-B2 | Peptide or peptidomimetic compounds containing the Arg-Gly-Asp sequence: new class of diagnostic noninvasive tracers as suitable tools for integrin alpha v beta 3-targeted therapy and imaging; antiproliferation agents; angiogenesis inhibititors; antitumor agents; anticarcinogenic agents; kits | ADVANCED ACCELERATOR APPLICATIONS (FR) | 2013-10-01 | — | — | US | disclosed |
| EP-1934248-B1 | SELECTIVE ALFAVBETA3 RECEPTOR PEPTIDE ANTAGONIST FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS | ADVANCED ACCELERATOR APPLIC (FR) | 2013-05-01 | — | — | EP | disclosed |
| US-20080213190-A1 | Selective Alfavbetas Receptor Peptide Antagonist for Therapeutic and Diagnostic Applications | ADVANCED ACCELERATOR APPLICATIONS (FR) | 2008-09-04 | — | — | US | disclosed |
| EP-1934248-A2 | SELECTIVE ALFAVBETA3 RECEPTOR PEPTIDE ANTAGONIST FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS | Del Gatto, Annarita (IT) | 2008-06-25 | — | — | EP | disclosed |
| US-7329644-B2 | Preparation and use of cyclic and branched peptides and their labelled derivatives as therapeutic agents, cholecystokinin agonists or antagonists, and diagnostic agents to identify and locate tumours | BRACCO IMAGING S.P.A. (IT) | 2008-02-12 | — | — | US | disclosed |
| WO-2007042241-A2 | SELECTIVE ALFAVBETA3 RECEPTOR PEPTIDE ANTAGONIST FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS | DEL GATTO ANNARITA (IT) | 2007-04-19 | — | — | WO | disclosed |
| EP-1390405-B1 | PREPARATION OF CHOLECYSTOKININ AGONISTS AND ANTAGONISTS AND THEIR THERAPEUTIC AND DIAGNOSTIC USE | BRACCO IMAGING SPA (IT) | 2007-01-24 | — | — | EP | disclosed |
| US-20040254339-A1 | Preparation and use of cyclic and branched peptides and their labelled derivatives as therapeutic agents, cholecystokinin agonists or antagonists, and diagnostic agents to identify and locate tumours | BRACCO IMAGING S.P.A. (IT) | 2004-12-16 | — | — | US | disclosed |
| EP-1390405-A2 | PREPARATION OF CHOLECYSTOKININ AGONISTS AND ANTAGONISTS AND THEIR THERAPEUTIC AND DIAGNOSTIC USE | Bracco Imaging S.p.A. (IT) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002094873-A2 | PREPARATION OF CHOLECYSTOKININ AGONISTS AND ANTAGONISTS, AND THEIR THERAPEUTIC AND DIAGNOSTIC USE | BRACCO IMAGING S.P.A. (IT) | 2002-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12473261-B2 | Amino acid compositions | ASNS, GLUL, ARGLU1 | SLC7A5 13/4885ALPI 3074/4885PKM 1493/4885 |
| US-12612370-B2 | Amino acid compositions | TNNT2, NPR1, NOS2 | SLC7A5 51/4885ALPI 3024/4885PKM 375/4885 |
| US-12448357-B1 | Amino acid compositions | SLC6A15, SLC1A5, SLC6A19 | SLC7A5 13/4885ALPI 1869/4885PKM 3048/4885 |
| US-12540119-B2 | Amino acid compositions | NOS2, NOS1, NOS3 | SLC7A5 26/4885ALPI 3397/4885PKM 176/4885 |
| US-20040254339-A1 | Preparation and use of cyclic and branched peptides and their labelled derivatives as therapeutic agents, cholecystokinin agonists or antagonists, and diagnostic agents to identify and locate tumours | CCKBR, CCKAR, GRPR | SLC7A5 182/4885ALPI 1381/4885PKM 982/4885 |
| US-12240819-B1 | Amino acid compositions | SLC10A2, SLC1A5, CPT1B | SLC7A5 10/4885ALPI 365/4885PKM 545/4885 |
| US-12577209-B2 | Amino acid compositions | ARG1, NOS1, NOS2 | SLC7A5 27/4885ALPI 3602/4885PKM 304/4885 |
| US-20250171406-A1 | AMINO ACID COMPOSITIONS | ASNS, GLUL, ARGLU1 | SLC7A5 14/4885ALPI 3020/4885PKM 1566/4885 |
| US-12577210-B2 | Amino acid compositions | NPR1, SLC1A5, SLC6A15 | SLC7A5 14/4885ALPI 4622/4885PKM 305/4885 |
| US-20080213190-A1 | Selective Alfavbetas Receptor Peptide Antagonist for Therapeutic and Diagnostic Applications | ITGAV, ITGB3, ITGA2B | SLC7A5 1049/4885ALPI 3141/4885PKM 3966/4885 |
| US-20250163001-A1 | AMINO ACID COMPOSITIONS | ASNS, GLUL, ARGLU1 | SLC7A5 13/4885ALPI 3074/4885PKM 1493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.