SCHEMBL9873447

SCHEMBL9873447

Cc1ccc(C2=Nc3cccc(Cl)c3C(=O)C2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.51
RAB9A P51151 4/20 0.51
SMN1; SMN2 Q16637 3/20 0.51
NPC1 O15118 3/20 0.51
KDM4E B2RXH2 2/20 0.51
PKM P14618 2/20 0.51
ALDH1A1 P00352 2/20 0.51
KMT2A Q03164 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
HTT P42858 1/20 0.36
THRB P10828 1/20 0.36
PBRM1 Q86U86 1/20 0.35
GRM2 Q14416 1/20 0.35
LMNA P02545 1/20 0.34
RXRA P19793 1/20 0.34
RXRB P28702 1/20 0.34
RXRG P48443 1/20 0.34
MAOB P27338 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9874259 0.81 MAPT (0.46) MAPTRAB9ASMN1; SMN2NPC1KDM4E
SCHEMBL9872061 0.80 RAB9A (0.45) MAPTRAB9ASMN1; SMN2NPC1KDM4E
SCHEMBL5637423 0.79 ACHE (0.35) MAPTKDM4EALDH1A1KMT2ATDP1
SCHEMBL9175744 0.72 ACHE (0.33) MAPTKDM4EALDH1A1KMT2ATDP1
SCHEMBL9874038 0.71 MAPT (0.44) MAPTRAB9ASMN1; SMN2NPC1KDM4E
SCHEMBL29640597 0.70 MAPT (0.70) MAPTRAB9ASMN1; SMN2NPC1KDM4E
SCHEMBL28574077 0.70 MAPT (0.70) MAPTRAB9ASMN1; SMN2NPC1KDM4E
SCHEMBL24743519 0.69 MAPT (0.50) MAPTRAB9ASMN1; SMN2NPC1KDM4E
SCHEMBL21794458 0.69 MAPT (0.55) MAPTRAB9ASMN1; SMN2NPC1KDM4E
SCHEMBL12266834 0.68 RAB9A (0.63) MAPTRAB9ASMN1; SMN2NPC1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5017576-A Antianxiolytic, hypnotic, anticonvulsant, antiepileptic RHONE-POULENC SANTE (FR) 1991-05-21 US disclosed