Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 2/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873447 | 0.81 | MAPT (0.51) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9872061 | 0.77 | RAB9A (0.45) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9177054 | 0.73 | TOP1 (0.41) | MAPTALDH1A1KDM4EPOLLHTT | |
| SCHEMBL15775204 | 0.73 | CYP19A1 (0.41) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL339611 | 0.73 | TP53 (0.42) | MAPTALDH1A1RAB9ANPC1RXFP1 | |
| SCHEMBL9875005 | 0.72 | MAPT (0.42) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL1045908 | 0.70 | TNKS (0.46) | MAPTALDH1A1RAB9AKDM4ETNKS | |
| SCHEMBL29640597 | 0.68 | MAPT (0.70) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28574077 | 0.68 | MAPT (0.70) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9872637 | 0.68 | MAPT (0.40) | MAPTALDH1A1RXFP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5017576-A | Antianxiolytic, hypnotic, anticonvulsant, antiepileptic | RHONE-POULENC SANTE (FR) | 1991-05-21 | — | — | US | disclosed |