Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249846 | 0.96 | ALDH1A1 (0.68) | ALDH1A1TSHRHPGDCA12L3MBTL1 | |
| SCHEMBL6259352 | 0.85 | ALDH1A1 (0.63) | ALDH1A1TSHRHPGDCA12L3MBTL1 | |
| SCHEMBL3202573 | 0.83 | ALDH1A1 (0.72) | ALDH1A1TSHRHPGDL3MBTL1TDP1 | |
| SCHEMBL7564163 | 0.83 | ALDH1A1 (0.61) | ALDH1A1TSHRHPGDCA12L3MBTL1 | |
| SCHEMBL68381 | 0.82 | ALDH1A1 (0.70) | ALDH1A1TSHRHPGDCA12L3MBTL1 | |
| SCHEMBL29699944 | 0.82 | ALDH1A1 (0.70) | ALDH1A1TSHRHPGDCA12L3MBTL1 | |
| SCHEMBL8576604 | 0.81 | ALDH1A1 (0.59) | ALDH1A1TSHRHPGDCA12L3MBTL1 | |
| SCHEMBL94769 | 0.81 | GPR35 (0.55) | ALDH1A1TSHRHPGDCA12L3MBTL1 | |
| SCHEMBL3884443 | 0.81 | ALDH1A1 (0.54) | ALDH1A1TSHRHPGDCA12L3MBTL1 | |
| SCHEMBL28859293 | 0.81 | ALDH1A1 (0.50) | ALDH1A1TSHRHPGDL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | disclosed |
| EP-0359335-A2 | Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance | CEDONA PHARMACEUTICALS B.V. (NL) | 1990-03-21 | — | — | EP | disclosed |