Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10238609 | 0.86 | LMNA (0.50) | TRPA1LMNAPBRM1 | |
| Nitric Acid SCHEMBL9872245 | 0.85 | GSR (0.51) | TRPA1LMNAGSRCYP2D6SRC | |
| SCHEMBL28658720 | 0.80 | SRC (0.40) | TRPA1TSHRLMNAGSRKDM4E | |
| SCHEMBL12859111 | 0.79 | TRPA1 (0.45) | TRPA1TSHRLMNAHTR2ATAAR1 | |
| SCHEMBL301347 | 0.77 | LMNA (0.44) | TRPA1TSHRLMNAKDM4EL3MBTL1 | |
| SCHEMBL8693287 | 0.77 | TSHR (0.48) | TRPA1TSHRLMNAHTR2ATAAR1 | |
| SCHEMBL8665401 | 0.77 | ALDH1A1 (0.50) | TRPA1TSHRLMNAHTR2AKDM4E | |
| SCHEMBL246459 | 0.77 | LMNA (0.44) | TRPA1TSHRLMNAKDM4EL3MBTL1 | |
| SCHEMBL548337 | 0.75 | TRPA1 (0.54) | TRPA1LMNATAAR1KDM4E | |
| SCHEMBL2126869 | 0.75 | TACR1 (0.50) | TRPA1HTR2ATAAR1DPP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | disclosed |
| EP-0359335-A2 | Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance | CEDONA PHARMACEUTICALS B.V. (NL) | 1990-03-21 | — | — | EP | disclosed |