Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CPA1 | P15085 | 3/20 | 0.35 |
| ▸ | ACP3 | P15309 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9875014 | 0.85 | TRPA1 (0.45) | GSRTRPA1LMNACYP2D6SRC | |
| Nitric Acid SCHEMBL9874855 | 0.82 | GSR (0.56) | GSRNPC1ADAM17TRPA1ALDH1A1 | |
| Nitric Acid SCHEMBL9803283 | 0.78 | GSR (0.53) | GSRNPC1ALDH1A1LMNAMEN1 | |
| Nitric Acid SCHEMBL9875712 | 0.74 | GSR (0.49) | GSRNPC1ADAM17TRPA1MEN1 | |
| Nitric Acid SCHEMBL9875242 | 0.74 | LMNA (0.41) | GSRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL10238609 | 0.74 | LMNA (0.50) | TRPA1LMNAMEN1KMT2A | |
| SCHEMBL9872237 | 0.73 | GSR (0.47) | GSRNPC1ADAM17ALDH1A1LMNA | |
| Nitric Acid SCHEMBL9838314 | 0.73 | ALDH1A1 (0.47) | GSRALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL3336779 | 0.72 | GSR (0.55) | GSRNPC1ADAM17TRPA1ALDH1A1 | |
| SCHEMBL28658720 | 0.72 | SRC (0.40) | GSRTRPA1ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | disclosed |
| EP-0359335-A2 | Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance | CEDONA PHARMACEUTICALS B.V. (NL) | 1990-03-21 | — | — | EP | disclosed |