Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873569 | 0.86 | TP53 (0.41) | TDP1TP53NPSR1HTTTSHR | |
| SCHEMBL9873566 | 0.86 | TP53 (0.41) | TDP1TP53NPSR1HTTTSHR | |
| SCHEMBL9875162 | 0.81 | NPSR1 (0.42) | TDP1TP53NPSR1HTTTSHR | |
| SCHEMBL9873486 | 0.79 | TSHR (0.41) | TDP1TP53NPSR1HTTTSHR | |
| SCHEMBL9873509 | 0.78 | TSHR (0.43) | TDP1TP53NPSR1HTTTSHR | |
| SCHEMBL9874015 | 0.76 | LMNA (0.40) | TDP1TP53NPSR1HTTTSHR | |
| SCHEMBL9872913 | 0.74 | KMT2A (0.41) | TP53HTTTSHRLMNAALDH1A1 | |
| SCHEMBL9873809 | 0.73 | LMNA (0.36) | TDP1TP53NPSR1HTTTSHR | |
| SCHEMBL2001481 | 0.70 | TSHR (0.52) | TDP1TP53NPSR1HTTTSHR | |
| SCHEMBL27213906 | 0.66 | CA12 (0.47) | TDP1TP53NPSR1HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4990508-A | Reduced side effects | TOYAMA CHEMICAL CO., LTD. (JP) | 1991-02-05 | — | — | US | disclosed |