SCHEMBL9876170

SCHEMBL9876170

O=C1ONC2(CCCCC2)C1N1C(=O)c2cccc3cccc(c23)C1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.42
ALDH1A1 P00352 6/20 0.42
HPGD P15428 4/20 0.40
CYP1A2 P05177 2/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
LMNA P02545 1/20 0.40
CYP1B1 Q16678 1/20 0.40
ERCC1 P07992 1/20 0.40
FEN1 P39748 1/20 0.40
ERCC4 Q92889 1/20 0.40
TYMS P04818 1/20 0.39
HEXA P06865 3/20 0.38
HEXB P07686 3/20 0.38
PARP1 P09874 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
HSD17B10 Q99714 2/20 0.38
NPSR1 Q6W5P4 1/20 0.38
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9875223 0.74 TDP1 (0.42) KDM4EALDH1A1HPGDCYP1A2CYP1B1
SCHEMBL11544600 0.66 KDM4E (0.51) KDM4EALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL11538199 0.65 TSHR (0.49) KDM4EALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL27538862 0.64 ALDH1A1 (0.46) KDM4EALDH1A1HPGDCYP1A2CYP1B1
SCHEMBL9876255 0.63 ALDH1A1 (0.41) KDM4EALDH1A1HPGDLMNACYP1B1
SCHEMBL11696500 0.63 KDM4E (0.58) KDM4EALDH1A1HPGDLMNAHEXA
SCHEMBL11692027 0.63 KDM4E (0.58) KDM4EALDH1A1HPGDLMNAHEXA
SCHEMBL9541318 0.63 CYP1B1 (0.46) KDM4EALDH1A1HPGDCYP1A2CYP1B1
SCHEMBL19876317 0.63 HTR2B (0.53) KDM4EALDH1A1HPGDCYP1B1ERCC1
SCHEMBL2175176 0.63 CRBN (0.78) ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5076831-A Herbicides BASF AKTIENGESELLSCHAFT (DE) 1991-12-31 US disclosed