Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 8/20 | 0.63 |
| ▸ | CTSS | P25774 | 5/20 | 0.61 |
| ▸ | CTSB | P07858 | 2/20 | 0.61 |
| ▸ | CTSL | P07711 | 1/20 | 0.61 |
| ▸ | REN | P00797 | 3/20 | 0.60 |
| ▸ | ACE | P12821 | 2/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.56 |
| ▸ | GNPAT | O15228 | 1/20 | 0.56 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
| ▸ | MME | P08473 | 1/20 | 0.53 |
| ▸ | CPA1 | P15085 | 1/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876540 | 1.00 | CTSK (0.63) | CTSKCTSSCTSBCTSLREN | |
| SCHEMBL22962442 | 1.00 | CTSK (0.63) | CTSKCTSSCTSBCTSLREN | |
| SCHEMBL22962239 | 0.95 | CTSK (0.61) | CTSKCTSSCTSBCTSLREN | |
| SCHEMBL29531081 | 0.94 | REN (0.65) | CTSKCTSSCTSBCTSLREN | |
| SCHEMBL29651477 | 0.93 | REN (0.57) | CTSKCTSSCTSBCTSLREN | |
| SCHEMBL22962429 | 0.91 | REN (0.61) | CTSKCTSSCTSBCTSLREN | |
| SCHEMBL11345784 | 0.91 | CTSK (0.63) | CTSKCTSSCTSBCTSLREN | |
| SCHEMBL28269191 | 0.90 | CTSS (0.60) | CTSKCTSSCTSBCTSLREN | |
| SCHEMBL28269194 | 0.90 | CTSS (0.60) | CTSKCTSSCTSBCTSLREN | |
| SCHEMBL29651429 | 0.90 | CTSS (0.60) | CTSKCTSSCTSBCTSLREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4992562-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4948913-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1990-08-14 | — | — | US | disclosed |
| US-4729985-A | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1988-03-08 | — | — | US | disclosed |
| EP-0212903-A2 | Polypeptide derivatives containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues | PFIZER INC. (US) | 1987-03-04 | — | — | EP | disclosed |