Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 3/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910 | 0.88 | CYP1A2 (0.44) | CYP1A2ALDH1A1HPGDMAPTGLA | |
| SCHEMBL7374426 | 0.73 | CYP1A2 (0.33) | CYP1A2ALDH1A1 | |
| SCHEMBL20659316 | 0.71 | MAPT (0.54) | CYP1A2ALDH1A1HPGDMAPTGLA | |
| SCHEMBL524746 | 0.69 | ALDH1A1 (0.46) | CYP1A2ALDH1A1HPGDMAPTGLA | |
| SCHEMBL2139252 | 0.68 | ALDH1A1 (0.44) | CYP1A2ALDH1A1HPGDMAPTGLA | |
| SCHEMBL16357 | 0.65 | KDM4E (0.32) | CYP1A2ALDH1A1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL16316 | 0.65 | MAP4K4 (0.34) | — | |
| SCHEMBL2671574 | 0.65 | NPC1 (0.47) | CYP1A2ALDH1A1MAPTRAB9ANPC1 | |
| SCHEMBL3032 | 0.64 | ALDH1A1 (0.44) | CYP1A2ALDH1A1HPGDMAPTGLA | |
| SCHEMBL449631 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0156433-B1 | ANTI-VIRALLY ACTIVE PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-27 | — | — | EP | claimed |
| EP-0156433-B1 | ANTI-VIRALLY ACTIVE PYRIDAZINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-02-27 | — | — | EP | disclosed |