Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10873379 | 0.95 | ALOX5 (0.59) | ALOX5PTGS1PTGS2 | |
| SCHEMBL10362090 | 0.88 | ALOX5 (0.52) | ALOX5PTGS1PTGS2 | |
| SCHEMBL10361597 | 0.86 | ALOX5 (0.53) | ALOX5PTGS1PTGS2 | |
| SCHEMBL10362643 | 0.83 | CYP3A4 (0.49) | PTGS1 | |
| SCHEMBL7975563 | 0.80 | PTPN1 (0.46) | ALOX5PTGS1PTGS2 | |
| SCHEMBL29637954 | 0.80 | GLA (0.60) | PTGS1 | |
| SCHEMBL29931049 | 0.80 | GLA (0.60) | PTGS1 | |
| SCHEMBL2887144 | 0.80 | GLA (0.60) | PTGS1 | |
| SCHEMBL2887149 | 0.80 | GLA (0.60) | PTGS1 | |
| SCHEMBL2744149 | 0.79 | CYP3A4 (0.61) | PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |