Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | BPTF | Q12830 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.32 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6530435 | 0.88 | NCF1 (0.46) | NCF1SIGMAR1CXCR4DRD3DRD2 | |
| SCHEMBL16767776 | 0.82 | SIGMAR1 (0.38) | SIGMAR1DRD3DRD2OPRM1 | |
| SCHEMBL2707078 | 0.80 | NCF1 (0.39) | NCF1BPTFCXCR4PRMT3CARM1 | |
| SCHEMBL12718264 | 0.80 | SIGMAR1 (0.37) | SIGMAR1DRD3DRD2OPRM1HTR4 | |
| SCHEMBL11445829 | 0.80 | SIGMAR1 (0.37) | SIGMAR1DRD3DRD2HTR4 | |
| SCHEMBL1075678 | 0.79 | — | — | |
| SCHEMBL9545164 | 0.76 | SIGMAR1 (0.35) | SIGMAR1DRD3DRD2HTR4 | |
| SCHEMBL8936092 | 0.75 | — | — | |
| SCHEMBL10828113 | 0.75 | — | — | |
| SCHEMBL7637341 | 0.72 | SIGMAR1 (0.33) | SIGMAR1DRD3DRD2OPRM1HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5066802-A | Multistep process from 2,4-difluoro-3-chloronitrobenzene and mercaptoisopropanol or mercaptopropanediol | MEDIOLANUM FARMACEUTICI SRL. (IT) | 1991-11-19 | — | — | US | disclosed |
| US-4923859-A | Pyrido-benzothiazine derivatives having high antibacterial activity and high bioavailability to tissues | MEDIOLANUM FARMACEUTICI, S.R.L. (IT) | 1990-05-08 | — | — | US | disclosed |
| EP-0310969-A2 | Pyrido-benzothiazine derivatives having high antibacterial activity and high bioavailability to tissues | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1989-04-12 | — | — | EP | disclosed |